By Oscar Bodansky (ed.), C.P. Stewart (ed.)
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Extra resources for Advances in Clinical Chemistry, Vol. 12
1. EFFECTS OF DIMINISHED FOOD INTAKE ON THE METABOLIC RESPONSE As described above, it is now fairly certain that the source of most of the additional nitrogen lost in the urine in the “flow” phase of the metabolic response to injury is labile body protein, and not liver or gut 24 D. P. CUTHBERTSON AND W. J. Rats fed a protein-free diet for some time before being given fracture of one femur will not show any protein catabolic response (Cl, M20) and also groups of rats fed to different levels of protein intake each showed a protein catabolic response proportional t o the preinjury level of intake, even when the dietary regime thereafter was changed simultaneous to fracture (M19).
Urine: Uropepsin. The increase in adrenal activity is accompanied by a rise in gastric acidity, pepsin concentration, and urinary uropepsin excretion, regardless of the presence of the vagus nerve or gastric antrum (D10, E2). The increase in uropepsin excretion closely parallels the increase in 17-hydroxycorticoid output. The maximum gastric and adrenal responses appear on the second to fourth day (G20). 3. HEMOGLOBIN AND EFFECT OF TRANSFUSION I n limb injuries, after blood loss there is usually a fairly rapid dilution of blood, first with protein-free or protein-poor fluid, but later chiefly 14 D.
However, studies on the effects of environmental stress are of relevance to the problem of the metabolic response to injury. METABOLISM DURING THE POSTINJUBY PEBIOD 27 Hale et al. (H2) have studied the effect of long-term exposure to 3"5"C, 24"-26"C, or 34"-35°C on tissue growth in the rat. Only the middle temperature range is within the normal thermoregulatory range of environmental temperature for the rat. They found kidney, liver, spleen, and testes weights to be linearly and inversely related to environmental temperature, while thymus weight was linearly and directly proportional to environmental temperature.
Advances in Clinical Chemistry, Vol. 12 by Oscar Bodansky (ed.), C.P. Stewart (ed.)